In Vitro Design and Evaluation of Sustained Release Matrix Tablets Containing Prazosin

Naresh Kshirasagar, Pranneth Gillela, Srilatha Malvey*

Abstract

The present investigation aimed to formulate and develop sustained-release tablets of Prazosin hydrochloride using the direct compression technique. Various polymers, including xanthan gum, HPMC K4M, and HPMC K100M, were employed to design nine formulations. Pre-compression and post-compression parameters were evaluated and found to be within pharmacopoeial limits. In vitro drug release studies were conducted for all formulations, among which formulation F-IX exhibited sustained drug release up to 24 hours. Further in vitro release studies of the optimized formulation were performed in phosphate buffer (pH 7.4) under varying conditions such as different concentrations of sodium lauryl sulfate (SLS), agitation speeds, and dissolution media. Optimal release conditions were observed with 1.5% SLS concentration, an agitation speed of 100 rpm, and a dissolution medium volume of 500 mL. Accelerated stability studies indicated that formulation F-IX remained stable for one month. Release kinetics analysis revealed that the optimized formulation followed the Korsmeyer–Peppas model, indicating a non-Fickian diffusion mechanism. Swelling studies further supported the sustained-release behavior of formulation F-IX.