Measurement Aspects of the Mishel Uncertainty in Illness Scale (MUIS) Related to Early-Stage Osteonecrosis of the Femoral Head (ONFH)

Michelle J Lespasio.

Abstract

This study proposal aims to examine uncertainty in illness in chronic disease among individuals with early-stage osteonecrosis of the femoral head (ONFH) and its relationships with symptom severity, quality of life (QoL), and psychological adjustment (PA), as well as its predictive role in patient outcomes. Secondary aims include quantifying the level of uncertainty in illness experienced by individuals with early-stage ONFH, evaluating the associations between uncertainty in illness and symptom severity, QoL, and PA, and determining the extent to which uncertainty in illness predicts patient outcomes, including psychological distress and QoL. In addition, it seeks to explore the relative contribution of uncertainty compared to clinical and demographic variables in explaining variation in patient outcomes and examine whether uncertainty differs across subgroups (e.g., age, gender, disease characteristics) supporting future assessment of measurement invariance and tailored interventions.