Abstract
Objective: The addition of tripeptide collagen (TC) supplements to otherwise healthy diets are claimed to exert benefit in some individuals. Liposomes may aid in protecting TC during early gut transit, improving small gut absorption and thus bioavailability. The aim of this paper is to investigate and summarise the existing literature on tripeptide collagen (TC) supplementation and evaluate reported outcomes from a consumer cohort using liposomal tripeptide collagen (LTC), specifically fish-derived Glycine-Prolene-Hydroxyproline (Gly-Pro-Hyp).
Materials and Methods: A literature review of TC supplementation was conducted. Additionally, an electronic questionnaire was independently formulated and distributed to 300 consenting adults who had been using LTC for at least one month. A total of 272 responses were received; 179 met inclusion criteria.
Results: Survey data shows reported improvement in well-being (78%), better skin quality (83%), reduction in skin disorders (58%), improved hair growth (70%), and reduction in joint pain (39%). Evidential support for nutritional tripeptides in the maintenance of well-being was corroborated in existing literature.
Conclusions: Existing literature suggests potential benefits of TC supplementation and qualitative findings in this work suggest that liposomal TC may offer enhanced improvements. Liposomal delivery may increase bioavailability, though further controlled studies are required.
James D. Frame (Snr), James D. Frame (Jnr).. Liposomes Containing Nutritional Tripeptides can Improve Well-Being, Hair Growth and Skin Radiance – a Summary of the Literature and Findings from a Large Cohort Customer Survey. Medical and Clinical Research: Open Access 2026 ; 7(1) : 1-5 . DOI: 10.52106/2766-3213.1062