Inflammation and Neuroinflammation Caused by Environmental Factors

Kurt Müller, Martina Wagner.

Abstract

A wide variety of non-physiological chemical and physical influences affect humans in all areas of modern life. These factors can trigger diseases and, through epigenetic effects, may also affect subsequent generations. Chronic exposure to environmental stressors induces inflammatory reactions that are associated, among others, with allergies, mast cell activation syndrome, and depression.

TRPV1 is a non-selective cation channel whose activation by chemicals is considered a key pathomechanism of MCS. Both endogenous stress responses and chronic inflammation can lead to increased oxidative stress, resulting in severe performance decline up to burnout or chronic fatigue syndrome.

The most important therapeutic principle and prerequisite for further therapeutic interventions is the interruption or elimination of disease triggering mechanisms.